Climara 50 (Estradiol 3.8mg). Product size: 1 box contains 4 patches. **** Promotion: Buy 10 boxes get 1 box free. Active Ingredients: Estradiol Valerate. Climara (Estradiol) contains Estradiol in patch form and is used for the treatment of moderate-to-severe vasomotor menopausal symptoms, vulval and vaginal atrophy, hypoestrogenism, and prevention of osteoporosis. Description Climara (Estradiol) is used for the treatment of moderate-to-severe vasomotor menopausal symptoms, vulval and vaginal atrophy, hypoestrogenism and prevention of osteoporosis. The Climara (Estradiol) patch releases the hormone estradiol continuously. It reaches the bloodstream through the skin (transdermally) and leads to a constant blood level of the hormone, relieving the symptoms.