Oestrogel. 1 tube with 80 grams of gel containing 60 mg of estradiol valerate and 1 plastic ruler for application in a paper box. Active ingredient: 17 beta-estradiol valerate 60 mg in 80 grams of gel. Oestrogel 60 mg is a gel for a cutaneous application containing 60 mg of Estradiol used in estrogen hormone replacement therapy (HRT) to substitute the lack of oestrogen production by the ovaries. It is used to relieve symptoms of menopause caused by oestrogen deficiency, such as hot flushes, excessive sweating, sleeplessness, vaginal dryness, headaches, mood swings, lack of concentration, and loss of energy. Oestrogel is also used as a prevention of postmenopausal bone loss (osteoporosis) and reduce the risk of fracture. Oestrogel stimulates the development of female sexual characteristics and is used as the oestrogen component of transgender hormone therapy for male to female transsexuals. Oestrogel contains the active ingredient estradiol valerate, exactly 17 beta-estradiol, the major and most active form of oestrogen produced by the ovaries, and is used for hormone replacement therapy (HRT). Oestrogel can be used as part of a gender reassignment program for male to female transsexuals, by providing a source of estradiol, the most active form of the female hormone oestrogen. Oestrogel stimulates the development of female secondary sexual characteristics, such as breast development, and also induce metabolic changes such as fat distribution to redefine the general body shape. Indications: oestrogen hormone replacement therapy. Side effects: the most frequently reported side effects when using Oestrogel are breast tenderness, breast pain, abdominal pain, nausea, oedema, and headache, skin rash and itching, insomnia, and depression.